§ 01 · Studies in design
Six studies. Pre-registered, peer-reviewed on completion.
Each study below has a designed protocol, target cohort and a target journal. The principal investigator slot fills as the advisory board confirms each chair. DOIs and full PDFs publish at peer-review acceptance. Until then, none of these are findings — they are commitments to a method.
- Study 01In design
HRV accuracy of optical PPG vs 12-lead ECG
PI to be confirmed · cardiology · Target: cardiology peer-reviewed journal
Acceptance threshold: r ≥ 0.90 vs clinical ECG
Protocol in design · target Q3 2026
- Study 02In design
Four-class sleep staging accuracy on a wrist-worn band
PI to be confirmed · sleep science · Target: digital-medicine peer-reviewed journal
Acceptance threshold: Cohen κ ≥ 0.75 vs polysomnography
Protocol in design · target Q4 2026
- Study 03In design
SpO₂ accuracy under skin-tone variation (Fitzpatrick I-VI)
PI to be confirmed · pulse-ox equity · Target: digital-health peer-reviewed journal
Acceptance threshold: MAE ≤ 2% across all skin tones
Protocol in design · target Q4 2026
- Study 04In design
Stress biomarker — overnight HRV correlated with morning cortisol
PI to be confirmed · endocrinology · Target: psychoneuroendocrinology peer-reviewed journal
Acceptance threshold: |r| ≥ 0.5 between LF/HF and cortisol AUC
Protocol in design · target Q1 2027
- Study 05In design
Longitudinal WVI predictive power for 30-day fatigue events
PI to be confirmed · public health · Target: open-access medical journal
Acceptance threshold: AUC ≥ 0.75
Cohort recruits at pool launch · target Q3 2027
- Study 06In design
Recovery score reproducibility — 6-month within-subject
PI to be confirmed · biosensors · Target: sensors / open-access
Acceptance threshold: ICC ≥ 0.80
Protocol in design · target Q1 2027
§ 02 · Scientific Advisory Board
Five seats. Confirmation announced when each chair signs.
The Wellex SAB will convene quarterly to review sensor changes, study protocols and risk disclosure. Five seats are open by design — names announce on confirmation, with full equity disclosure on /trust at that time. We do not publish names before contracts are countersigned.
- Cc·T
Cardiology chair · TBA
Chair · Cardiology
Seat open · senior clinical research
HRV validation, autonomic nervous system biomarkers
- Ssc·T
Sleep science chair · TBA
Sleep Science
Seat open · polysomnography lab
Polysomnography, four-class staging, REM density
- Pec·T
Pulse-ox equity chair · TBA
Pulse Oximetry · Equity
Seat open · clinical-research hospital
SpO₂ accuracy across skin tones, FDA regulatory pathway
- E/sc·T
Endocrinology / stress chair · TBA
Endocrinology · Stress
Seat open · affective-computing or endocrinology lab
Cortisol-HRV correlation, allostatic load modelling
- Cl·T
Cohort lead · TBA
Public Health · Longitudinal
Seat open · public-health research
Cohort design, fatigue prediction, real-world evidence
§ 03 · Acceptance brackets vs the field
What we have to beat. Honest about where we won’t.
We commit to the comparison brackets in advance. Polar H10 (chest strap) is the field reference for HRV during burst exercise — we don’t pretend to beat it there. Where Wellex needs to land to be defensible: see the column below.
| Metric | Wellex target | Polar H10 | Oura Gen3 | Whoop 4 |
|---|---|---|---|---|
| HRV (overnight) vs ECG | target r ≥ 0.90 | r ≈ 0.94 | r ≈ 0.82 | r ≈ 0.79 |
| Sleep-stage accuracy (κ) | target ≥ 0.75 | — | ≈ 0.65 | ≈ 0.69 |
| SpO₂ MAE (all skin tones) | target ≤ 2.0% | — | ≈ 2.6% | — |
| Continuous HR during burst | good | best | fair | good |
| Battery (days) | 14 | 1 | 6 | 4 |
| Form factor weight | 8.5g | 63g | 4-6g | 33g |
§ 04 · Longitudinal cohort plan
12-month study, recruits at pool launch.
The longitudinal WVI cohort is designed as opt-in for active members at pool launch. Target n ≥ 1,000, twelve-month observation window, monthly WVI deciles published as the cohort matures. The chart below is the target trajectory the cohort will be measured against — not data we already have.
Pre-publication · stay close